Genomic approaches in breast cancer research

Brief Funct Genomics. 2013 Sep;12(5):391-6. doi: 10.1093/bfgp/elt019. Epub 2013 Jun 20.

Abstract

Microarray technologies provide high-throughput analysis of genes that are differentially expressed in humans and other species, and thereby provide a means to measure how biological systems are altered during development or disease states. Within, we review how high-throughput genomic technologies have increased our understanding about the molecular complexity of breast cancer, identified distinct molecular phenotypes and how they can be used to increase the accuracy of predicted clinical outcome.

Keywords: breast cancer; genomics; histology; microarray; tumor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomedical Research*
  • Breast Neoplasms / classification
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology
  • Female
  • Gene Expression Profiling
  • Genomics / methods*
  • Humans
  • Neoplasm Grading
  • Signal Transduction / genetics