Engineering peripheral nerve repair

Curr Opin Biotechnol. 2013 Oct;24(5):887-92. doi: 10.1016/j.copbio.2013.05.006. Epub 2013 Jun 19.

Abstract

Current approaches for treating peripheral nerve injury have resulted in promising, yet insufficient functional recovery compared to the clinical standard of care, autologous nerve grafts. In order to design a construct that can match the regenerative potential of the autograft, all facets of nerve tissue must be incorporated in a combinatorial therapy. Engineered biomaterial scaffolds in the future will have to promote enhanced regeneration and appropriate reinnervation by targeting the highly sensitive response of regenerating nerves to their surrounding microenvironment.

Publication types

  • Review

MeSH terms

  • Animals
  • Axons / drug effects
  • Axons / physiology
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / pharmacology
  • Electric Stimulation
  • Guided Tissue Regeneration
  • Humans
  • Nerve Regeneration* / drug effects
  • Peripheral Nerve Injuries / pathology
  • Peripheral Nerve Injuries / therapy*
  • Peripheral Nerves / drug effects
  • Peripheral Nerves / pathology
  • Peripheral Nerves / physiology*
  • Tissue Engineering*
  • Tissue Scaffolds

Substances

  • Biocompatible Materials