Efficacy of Amphotericin B at Suboptimal Dose Combined with Voriconazole in a Murine Model of Aspergillus fumigatus Infection with Poor In Vivo Response to the Azole

Marcelo Sandoval-Denis; F Javier Pastor; Javier Capilla; Josep Guarro

doi:10.1128/AAC.00563-13

Efficacy of Amphotericin B at Suboptimal Dose Combined with Voriconazole in a Murine Model of Aspergillus fumigatus Infection with Poor In Vivo Response to the Azole

Antimicrob Agents Chemother. 2013 Sep;57(9):4540-4542. doi: 10.1128/AAC.00563-13. Epub 2013 Jun 24.

Authors

Marcelo Sandoval-Denis¹, F Javier Pastor¹, Javier Capilla¹, Josep Guarro²

Affiliations

¹ Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain.
² Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain [email protected].

Abstract

The combination of amphotericin B at a suboptimal dose (0.3 mg/kg) with voriconazole has shown efficacy in prolonging survival and reducing tissue burden in a murine model of disseminated infection by an isolate of Aspergillus fumigatus that had showed a poor in vivo response to the azole. The efficacy of the combined treatment was higher than that obtained with amphotericin B at 0.8 mg/kg.