NLRP6 in infection and inflammation

Microbes Infect. 2013 Sep-Oct;15(10-11):661-8. doi: 10.1016/j.micinf.2013.06.009. Epub 2013 Jun 28.

Abstract

NLRs play fundamental roles in host-defense and inflammatory disorders. NLRP6 is a newly characterized member of this family that inhibits NF-κB and MAP-kinase dependent immune signaling to hamper anti-microbial defense. Further, NLRP6 regulates intestinal inflammation by maintaining gut microbiota composition. In this review, we examine the recent studies and emphasize the key functions regulated by NLRP6.

Keywords: Infection; Innate immunity; Intestinal homeostasis; Microbiota; NLR; NLRP6.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Inflammation / physiopathology*
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • MAP Kinase Signaling System*
  • Microbiota / immunology*
  • NF-kappa B / antagonists & inhibitors*

Substances

  • Intracellular Signaling Peptides and Proteins
  • NF-kappa B
  • NLRP6 protein, human