A tandem organocatalytic α-chlorination-aldol reaction that proceeds with dynamic kinetic resolution: a powerful tool for carbohydrate synthesis

Org Lett. 2013 Jul 19;15(14):3554-7. doi: 10.1021/ol401370b. Epub 2013 Jul 2.

Abstract

A tandem, proline-catalyzed α-chlorination/aldol reaction is described that involves a dynamic kinetic resolution of α-chloroaldehyde intermediates. The resulting syn-chlorohydrins are produced with good to excellent diastereoselectivity in high enantiopurity and provide new opportunities for the synthesis of carbohydrates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbohydrates / chemical synthesis*
  • Carbohydrates / chemistry
  • Catalysis
  • Halogenation
  • Kinetics
  • Molecular Dynamics Simulation
  • Molecular Structure
  • Proline / chemistry*
  • Stereoisomerism

Substances

  • Carbohydrates
  • Proline