Slowing down DNA translocation through solid-state nanopores by pressure

Small. 2013 Dec 20;9(24):4112-7. doi: 10.1002/smll.201301263. Epub 2013 Jul 5.

Abstract

The effect of applied pressure on event duration distributions in 3 kb dsDNA translocation is systematically investigated. The effects of pressure magnitude and nanopore size on the length discrimination between 615 bp and 1.14 kbp dsDNA is studied. The pressure-controlled DNA translocation in solid-state nanopores makes a significant contribution to improve the temporal resolution in DNA single-molecule detection.

Keywords: DNA translocation; pressure gradients; short molecule selectivity; solid-state nanopores.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Arabidopsis / genetics
  • DNA / analysis*
  • DNA / chemistry
  • Escherichia coli / genetics
  • Hydrogen-Ion Concentration
  • Models, Theoretical
  • Molecular Dynamics Simulation
  • Nanopores*
  • Nanotechnology / methods*
  • Nucleic Acid Conformation
  • Poisson Distribution
  • Pressure

Substances

  • DNA