Abstract
In order to establish quantitative relationships between the antibacterial activities of a number of thienyl- and furyl-benzimidazoles and benzoxazoles, the biological data were measured homogeneously for a selected set of 16 representative compounds of the available set of 103. The data were analyzed by the PLS method. The results of linear PLS modelling and PLS response surface modelling permitted a straightforward interpretation of the structural features relevant to the activities and the prediction of a possible optimal structure.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents
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Anti-Infective Agents / pharmacology*
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Antifungal Agents / pharmacology*
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Bacteria / drug effects
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Benzimidazoles / chemical synthesis*
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Benzimidazoles / pharmacology
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Benzoxazoles / chemical synthesis*
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Benzoxazoles / pharmacology
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Chemical Phenomena
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Chemistry
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Fungi / drug effects
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Furans / chemical synthesis
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Furans / pharmacology
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Structure-Activity Relationship
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Thiophenes / chemical synthesis
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Thiophenes / pharmacology
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antifungal Agents
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Benzimidazoles
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Benzoxazoles
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Furans
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Thiophenes