Effects of animal liver and bile extracts on biochemical values of rat ethanol-induced fatty liver

Anim Sci J. 2014 Jan;85(1):75-80. doi: 10.1111/asj.12088. Epub 2013 Jul 11.

Abstract

The purposes of this study were to assess the improvement of fatty liver induced by ethanol with animal liver and bile extracts. This research aimed to increase the economic values of animal liver and bile extracts and used these to reduce damage of ethanol-induced fatty liver. Extracts came from animal liver and bile, including pig bile powder, pig liver extract, a mixture of pig bile powder and pig liver extract, chicken bile powder, chicken liver extract, and a mixture of chicken bile powder and chicken liver extract, and these were fed to Long-Evans rats. The results showed that rats fed ethanol for long terms could increase values of aspartate transaminase, cholesterol, γ-glutamy-transferase and alkaline phosphatase. Pig bile powder could decrease the values of aspartate transaminase, cholesterol and γ-glutamy-transferase. The significances also decreased on aspartate transaminase, γ-glutamy-transferase and aspartate transaminase, which were carried out with the pig liver extract treatment. These results suggest pig bile and liver extracts have high potential to improve rats' ethanol-induced fatty liver with serum biochemical parameters.

Keywords: bile; ethanol-induced fatty liver; extract; liver.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaline Phosphatase / blood
  • Animals
  • Aspartate Aminotransferases / blood
  • Bile / chemistry*
  • Chickens
  • Cholesterol / blood
  • Fatty Liver, Alcoholic / blood
  • Fatty Liver, Alcoholic / therapy*
  • Liver / chemistry*
  • Male
  • Rats, Long-Evans
  • Swine
  • Tissue Extracts / pharmacology
  • Tissue Extracts / therapeutic use*
  • gamma-Glutamyltransferase / blood

Substances

  • Tissue Extracts
  • Cholesterol
  • gamma-Glutamyltransferase
  • Aspartate Aminotransferases
  • Alkaline Phosphatase