Paramagnetic solid lipid nanoparticles as a novel platform for the development of molecular MRI probes

Gabriele A Rolla; Mauro Botta; Lorenzo Tei; Claudia Cabella; Simona Ghiani; Chiara Brioschi; Alessandro Maiocchi

doi:10.1002/chem.201301837

Paramagnetic solid lipid nanoparticles as a novel platform for the development of molecular MRI probes

Chemistry. 2013 Aug 19;19(34):11189-93. doi: 10.1002/chem.201301837. Epub 2013 Jul 10.

Authors

Gabriele A Rolla¹, Mauro Botta, Lorenzo Tei, Claudia Cabella, Simona Ghiani, Chiara Brioschi, Alessandro Maiocchi

Affiliation

¹ Dipartimento di Scienze e Innovazione Tecnologica, Università degli Studi del Piemonte Orientale Amedeo Avogadro, Viale T. Michel 11, 15121 Alessandria, Italy.

PMID: 23843364
DOI: 10.1002/chem.201301837

Abstract

Highly efficient magnetic resonance imaging (MRI) probes have been prepared by loading Gd(III) complexes on the surface of solid lipid nanoparticles (pSLNs). Applicability as molecular imaging probes is demonstrated by an in vitro model study with targeted pSLNs.

Keywords: contrast agents; lanthanides; lipidic nanoparticles; magnetic resonance imaging; relaxivity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Coordination Complexes / chemistry
Gadolinium / chemistry
Humans
Lipids / chemistry*
Magnetic Resonance Imaging
Magnetics
Microscopy, Confocal
Molecular Probes / chemistry*
Nanoparticles / chemistry*

Substances

Coordination Complexes
Lipids
Molecular Probes
Gadolinium