Abstract
New antifungal antibiotics pradimicins D and E were isolated from the culture filtrates of Actinomadura hibisca P157-2 (ATCC 53557) and its mutant A2660 (ATCC 53762). The structure of pradimicin D is N-[[(5S,6S)-5-O-[4,6-dideoxy-4-(methylamino)-3-O-(beta-D- xylopyranosyl)-beta-D-galactopyranosyl]-5,6,8,13-tetrahydro-1,6,9,14- tetrahydroxy-11-methoxy-3-methyl-8,13-dioxobenzo[a]naphthacen++ +-2-yl] carbonyl]glycine, based on spectral analyses compared to pradimicin A. Pradimicin E is the des-N-methyl analog of pradimicin D. Pradimicins D and E were equal in activity to pradimicin A in vitro against a variety of fungi and in vivo against Candida albicans A9540 in mice.
MeSH terms
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Actinomycetales / genetics
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Actinomycetales / metabolism*
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Animals
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Anthracyclines*
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Antibiotics, Antineoplastic / analysis
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Antibiotics, Antineoplastic / biosynthesis*
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Antibiotics, Antineoplastic / isolation & purification
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Antibiotics, Antineoplastic / pharmacology
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Antibiotics, Antineoplastic / therapeutic use
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Antifungal Agents / biosynthesis*
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Candidiasis / drug therapy*
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Fermentation
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Fungi / drug effects*
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Magnetic Resonance Spectroscopy
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Male
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Mass Spectrometry
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Mice
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Mice, Inbred ICR
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Molecular Structure
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Mutation
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Spectrophotometry, Ultraviolet
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Yeasts / drug effects
Substances
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Anthracyclines
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Antibiotics, Antineoplastic
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Antifungal Agents
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pradimicin E
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pradimicin D