Abstract
We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Cell Line, Tumor
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Drug Delivery Systems
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Emulsions / chemistry*
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Flow Cytometry
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Humans
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Integrin alphaVbeta3* / chemistry
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Matrix Metalloproteinase 2* / chemistry
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Mice
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Microscopy, Atomic Force
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Models, Molecular
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Nanoparticles / chemistry*
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Oligopeptides* / chemistry
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Surface Properties
Substances
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Emulsions
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Integrin alphaVbeta3
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Oligopeptides
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arginyl-glycyl-aspartic acid
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Matrix Metalloproteinase 2