Counting gephyrins, one at a time: a nanoscale view on the inhibitory postsynapse

Martin Heine; Anna Karpova; Eckart D Gundelfinger

doi:10.1016/j.neuron.2013.07.004

Counting gephyrins, one at a time: a nanoscale view on the inhibitory postsynapse

Neuron. 2013 Jul 24;79(2):213-6. doi: 10.1016/j.neuron.2013.07.004.

Authors

Martin Heine¹, Anna Karpova, Eckart D Gundelfinger

Affiliation

¹ Molecular Physiology Research Group, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany.

PMID: 23889929
DOI: 10.1016/j.neuron.2013.07.004

Abstract

Gephyrin is the key scaffolding molecule organizing the postsynaptic density at inhibitory synapses. Utilizing localization microscopy, Specht et al. (2013) report in this issue of Neuron on the quantitative assessment of gephyrin clusters and associated glycine receptors and GABAA receptors.

Publication types

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MeSH terms

Animals
Carrier Proteins / ultrastructure*
Membrane Proteins / ultrastructure*
Nanostructures / chemistry*
Nanostructures / ultrastructure*
Neural Inhibition / physiology*
Synapses / ultrastructure*

Substances

Carrier Proteins
Membrane Proteins
gephyrin