A highly sensitive and genetically encoded fluorescent reporter for ratiometric monitoring of quinones in living cells

Chem Commun (Camb). 2013 Sep 21;49(73):8027-9. doi: 10.1039/c3cc44534h. Epub 2013 Aug 1.

Abstract

The transcriptional regulator QsrR is converted into a genetically encoded fluorescent probe capable of ratiometric monitoring of quinones in living cells with high sensitivity and selectivity.

MeSH terms

  • Fluorescent Dyes* / chemistry
  • Gene Expression Regulation
  • HeLa Cells
  • Humans
  • Limit of Detection
  • Luminescent Proteins / chemistry*
  • Luminescent Proteins / genetics
  • Molecular Imaging
  • Naphthoquinones / chemistry
  • Quinones / analysis
  • Quinones / chemistry*

Substances

  • Fluorescent Dyes
  • Luminescent Proteins
  • Naphthoquinones
  • Quinones
  • plumbagin