T model of growth and its application in systems of tumor-immune dynamics

Math Biosci Eng. 2013 Jun;10(3):925-38. doi: 10.3934/mbe.2013.10.925.

Abstract

In this paper we introduce a new growth model called T growth model. This model is capable of representing sigmoidal growth as well as biphasic growth. This dual capability is achieved without introducing additional parameters. The T model is useful in modeling cellular proliferation or regression of cancer cells, stem cells, bacterial growth and drug dose-response relationships. We recommend usage of the T growth model for the growth of tumors as part of any system of differential equations. Use of this model within a system will allow more flexibility in representing the natural rate of tumor growth. For illustration, we examine some systems of tumor-immune interaction in which the T growth rate is applied. We also apply the model to a set of tumor growth data.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cell Proliferation
  • Humans
  • Logistic Models
  • Mathematical Concepts
  • Models, Biological*
  • Neoplasms / immunology*
  • Neoplasms / pathology*
  • Neoplasms / therapy
  • Nonlinear Dynamics
  • Population Dynamics
  • RNA Interference
  • Systems Biology