Frequency domains of resting state default mode network activity in schizophrenia

Gianluca Mingoia; Kerstin Langbein; Maren Dietzek; Gerd Wagner; Stefan Smesny; Sigrid Scherpiet; Raka Maitra; Jürgen R Reichenbach; Ralf G M Schlösser; Christian Gaser; Heinrich Sauer; Igor Nenadic

doi:10.1016/j.pscychresns.2013.05.013

Frequency domains of resting state default mode network activity in schizophrenia

Psychiatry Res. 2013 Oct 30;214(1):80-2. doi: 10.1016/j.pscychresns.2013.05.013. Epub 2013 Aug 1.

Authors

Gianluca Mingoia¹, Kerstin Langbein, Maren Dietzek, Gerd Wagner, Stefan Smesny, Sigrid Scherpiet, Raka Maitra, Jürgen R Reichenbach, Ralf G M Schlösser, Christian Gaser, Heinrich Sauer, Igor Nenadic

Affiliation

¹ Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.

PMID: 23916248
DOI: 10.1016/j.pscychresns.2013.05.013

Abstract

Probabilistic independent component analysis was applied to identify the default mode network (DMN) in resting state data obtained with functional magnetic resonance imaging from 25 DSM-IV schizophrenia and 25 matched healthy subjects. Power spectrum analysis showed a significant diagnosis × frequency interaction and higher power in one frequency band, indicating an alteration of DMN frequency spectrum in schizophrenia.

Keywords: Cortex; Default mode network (DMN); Power spectrum analysis; Probabilistic independent component analysis (pICA); Resting state; Schizophrenia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Brain / physiopathology*
Cerebral Cortex
Female
Functional Neuroimaging
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Net / physiopathology*
Schizophrenia / physiopathology*