Abstract
Four metabolites, teraspiridoles A-D (2-5), formed from the merger of a diterpene and modified indole scaffold were obtained from an Aspergillus terreus isolate. The structures and absolute configurations of these natural products were established using NMR, mass spectrometry, Marfey's method, VCD, and ECD data. Teraspiridole B (3) exhibited weak inhibition of planaria regeneration/survival.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Aspergillus / chemistry*
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Diterpenes / chemical synthesis
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Indole Alkaloids / chemical synthesis*
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Indole Alkaloids / chemistry
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Indole Alkaloids / isolation & purification
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Indole Alkaloids / pharmacology*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / chemistry
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Spiro Compounds / isolation & purification
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Spiro Compounds / pharmacology*
Substances
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Diterpenes
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Indole Alkaloids
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Spiro Compounds