Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys

J Virol. 2013 Oct;87(20):11292-9. doi: 10.1128/JVI.01643-13. Epub 2013 Aug 7.

Abstract

Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs), rarely transmit SIV via breast-feeding. In order to examine the genetic diversity of breast milk SIV variants in this limited-transmission setting, we performed phylogenetic analysis on envelope sequences of milk and plasma SIV variants of AGMs. Low-diversity milk virus populations were compartmentalized from that in plasma. However, this compartmentalization was transient, as the milk virus lineages did not persist longitudinally.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Chlorocebus aethiops
  • Cluster Analysis
  • Female
  • Gene Products, env / genetics
  • Genetic Variation*
  • Milk, Human / virology*
  • Phylogeny
  • Plasma / virology
  • Sequence Analysis, DNA
  • Simian Acquired Immunodeficiency Syndrome / virology*
  • Simian Immunodeficiency Virus / classification*
  • Simian Immunodeficiency Virus / genetics
  • Simian Immunodeficiency Virus / isolation & purification*

Substances

  • Gene Products, env