Delayed eye and other consequences from exposure to methyl isocyanate: 93% follow up of exposed and unexposed cohorts in Bhopal

Br J Ind Med. 1990 Aug;47(8):553-8. doi: 10.1136/oem.47.8.553.

Abstract

A follow up study three years after exposure to methyl isocyanate in 93% of exposed survivors and "control" residents in 10 Bhopali communities showed an excess of eye irritation, eyelid infection, cataract, and a decrease in visual acuity among the exposed people. Breathlessness was twice as common in the heavily exposed clusters as those with lower exposure, a trend that could not be explained by different age or smoking patterns (OR 2.05, 95% CI 1.36-3.08). Case referent analysis of outpatient attendances at Bhopal Eye Hospital, considering patients with severe refractive errors and astigmatism as "controls," showed a 40% increased risk of trachoma, 36% increased risk of other lid infections, and 45% increased risk of irritant symptoms among previously exposed people. "Bhopal eye syndrome" may thus include full resolution of the initial interpalpebral superficial erosion, a subsequent increased risk of eye infections, hyperresponsive phenomena (irritation, watering, and phlyctens), and possibly cataracts. It remains to be confirmed whether this reflects a more generalised disease as a consequence of previous exposure to methyl isocyanate or whether it is only the eye that is affected.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Accidents, Occupational*
  • Adolescent
  • Adult
  • Cataract / chemically induced
  • Child
  • Child, Preschool
  • Cohort Studies
  • Cyanates / poisoning*
  • Environmental Exposure
  • Eye Diseases / chemically induced*
  • Female
  • Follow-Up Studies
  • Humans
  • India
  • Infant
  • Isocyanates*
  • Male
  • Middle Aged
  • Visual Acuity / drug effects

Substances

  • Cyanates
  • Isocyanates
  • methyl isocyanate