Abstract
In this communication, we present the synthesis of new platinum complexes based on hydroxyquinoline ligands. We demonstrate the importance and the role of the halogen substitution as well as the chelation, which are essential structural characteristics for finding good cytotoxicities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Clioquinol / chemistry*
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Crystallography, X-Ray
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Halogens / chemistry*
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HeLa Cells
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Humans
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Hydroxyquinolines / chemistry*
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Ligands
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Models, Molecular
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Molecular Structure
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Organoplatinum Compounds / chemical synthesis
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Organoplatinum Compounds / chemistry
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Organoplatinum Compounds / pharmacology*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Halogens
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Hydroxyquinolines
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Ligands
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Organoplatinum Compounds
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Clioquinol