Improved chiral SFC screening for analytical method development

Wes Schafer; Tilak Chandrasekaran; Zainab Pirzada; Chaowei Zhang; Xiaoyi Gong; Mirlinda Biba; Erik L Regalado; Christopher J Welch

doi:10.1002/chir.22218

Improved chiral SFC screening for analytical method development

Chirality. 2013 Nov;25(11):799-804. doi: 10.1002/chir.22218. Epub 2013 Aug 15.

Authors

Wes Schafer¹, Tilak Chandrasekaran, Zainab Pirzada, Chaowei Zhang, Xiaoyi Gong, Mirlinda Biba, Erik L Regalado, Christopher J Welch

Affiliation

¹ Analytical Chemistry, Merck Research Laboratories, Rahway, New Jersey.

PMID: 23946148
DOI: 10.1002/chir.22218

Abstract

In this study we describe the evaluation of a recently developed supercritical fluid chromatography (SFC) instrument for automated chiral SFC method development. The greatly improved gradient dwell volume and liquid flow control of the new instrument in combination with the use of shorter columns containing smaller stationary phase particles affords chiral SFC method development that is faster and more universal than previous systems.

Keywords: SFC; chiral screening; fast analysis; method development.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromatography / methods*
Stereoisomerism
Stilbenes / chemistry

Substances

Stilbenes
stilbene oxide