Abstract
A novel series of polyphenols 4-9 were synthesized by the reaction of catechol with dehydroabietylamine derivatives. The antitumor activities of these compounds against L02 and HepG2 cells were investigated. Among them, compounds 4, 5, and 9 can inhibit HepG2 cells viability, but have lower inhibitory effect on L02 cells in the same concentration, indicating their potential for further development. Meanwhile, the novel series of polyphenols exhibited stronger radical-scavenging activities than the control groups.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Antioxidants / chemical synthesis
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Antioxidants / chemistry
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Antioxidants / pharmacology*
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Biphenyl Compounds / pharmacology
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Catechols / chemistry
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Diterpenes / chemical synthesis
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Diterpenes / chemistry
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Diterpenes / pharmacology*
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Free Radical Scavengers / chemical synthesis
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / pharmacology*
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Hep G2 Cells
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Humans
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Models, Chemical
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Molecular Structure
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Picrates / pharmacology
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Polyphenols / chemical synthesis
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Polyphenols / chemistry
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Polyphenols / pharmacology*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Antioxidants
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Biphenyl Compounds
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Catechols
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Diterpenes
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Free Radical Scavengers
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Picrates
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Polyphenols
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1,1-diphenyl-2-picrylhydrazyl
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catechol