Impact of palifermin on intestinal mucositis of HSCT recipients after BEAM

Bone Marrow Transplant. 2014 Jan;49(1):8-10. doi: 10.1038/bmt.2013.118. Epub 2013 Aug 19.

Abstract

The matched-control study failed to show a clinical relevant impact of palifermin on intestinal mucositis, although there was a reduced inflammatory response and less febrile neutropenia among patients who had no bacteraemia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols
  • Bacteremia / etiology
  • C-Reactive Protein / metabolism
  • Carmustine
  • Case-Control Studies
  • Cytarabine
  • Etoposide
  • Febrile Neutropenia / etiology
  • Female
  • Fibroblast Growth Factor 7 / therapeutic use*
  • Hematopoietic Stem Cell Transplantation / adverse effects
  • Humans
  • Inflammation
  • Intestinal Mucosa / pathology*
  • Male
  • Melphalan
  • Middle Aged
  • Mucositis / drug therapy*
  • Neutropenia
  • Young Adult

Substances

  • Cytarabine
  • Fibroblast Growth Factor 7
  • Etoposide
  • C-Reactive Protein
  • Melphalan
  • Carmustine

Supplementary concepts

  • BEAM regimen