Use of in situ atomic force microscopy to follow phase changes at crystal surfaces in real time

Ranjit Thakuria; Mark D Eddleston; Ernest H H Chow; Gareth O Lloyd; Barry J Aldous; Joseph F Krzyzaniak; Andrew D Bond; William Jones

doi:10.1002/anie.201302532

Use of in situ atomic force microscopy to follow phase changes at crystal surfaces in real time

Angew Chem Int Ed Engl. 2013 Sep 27;52(40):10541-4. doi: 10.1002/anie.201302532. Epub 2013 Aug 16.

Authors

Ranjit Thakuria¹, Mark D Eddleston, Ernest H H Chow, Gareth O Lloyd, Barry J Aldous, Joseph F Krzyzaniak, Andrew D Bond, William Jones

Affiliation

¹ Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (UK); Department of Chemical Sciences, Tezpur University, Napaam, Tezpur-784 028, Assam (India).

PMID: 23955996
DOI: 10.1002/anie.201302532

Abstract

AFM of cocrystals: Atomic force microscopy can be used to observe phase changes at crystal surfaces where the transformation is accompanied by a change in the spacing between layers of molecules. The conversion of a metastable polymorph of the caffeine-glutaric acid cocrystal into the thermodynamically stable form was analyzed continuously in situ using intermittent-contact-mode atomic force microscopy.

Keywords: atomic force microscopy; cocrystals; phase transitions; polymorphism; surface analysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Caffeine / chemistry
Crystallization*
Glutarates / chemistry
Microscopy, Atomic Force / methods*
Phase Transition
Surface Properties
Thermodynamics

Substances

Glutarates
Caffeine
glutaric acid