A highly specific BODIPY-based probe localized in mitochondria for HClO imaging

Analyst. 2013 Oct 21;138(20):6091-6. doi: 10.1039/c3an01152f. Epub 2013 Aug 20.

Abstract

An oxime containing fluorescent probe based on a BODIPY scaffold was successfully designed and used for HClO determination with rapid response, low detection limits and high selectivity. Confocal fluorescence microscopy demonstrated that the probe could permeate the mitochondria and made possible the fast fluorescent imaging of endogenous HClO.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boron Compounds / chemistry*
  • Fluorescent Dyes / chemistry*
  • Humans
  • Hypochlorous Acid / chemistry*
  • MCF-7 Cells
  • Mitochondria / chemistry*
  • Spectrometry, Fluorescence / methods

Substances

  • 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
  • Boron Compounds
  • Fluorescent Dyes
  • Hypochlorous Acid