Morphologically virus-like fullerenol nanoparticles act as the dual-functional nanoadjuvant for HIV-1 vaccine

Adv Mater. 2013 Nov 6;25(41):5928-36. doi: 10.1002/adma.201300583. Epub 2013 Aug 21.

Abstract

Fullerenol, which self-assembles into virus-sized nanoparticles, is designed as a dual-functional nanoadjuvant to generate comparable immune responses to the HIV DNA vaccine. It shows promising adjuvant activity via various immunization routes, decreasing the antigen dosage and immunization frequency while maintaining immunity levels and inducing TEM -biased immunity to combat the infection at early stage. The underlying mechanisms by which fullerenol-based formulation induces above-mentioned polyvalent immune responses are involved in activating multiple TLRs signaling pathways.

Keywords: HIV-1; fullerenol; nano-adjuvant; vaccine; virus-like particle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS Vaccines / adverse effects
  • AIDS Vaccines / chemistry*
  • AIDS Vaccines / immunology
  • Adjuvants, Immunologic / chemistry*
  • Adjuvants, Immunologic / pharmacology
  • Animals
  • Fullerenes / adverse effects
  • Fullerenes / chemistry*
  • Fullerenes / immunology
  • HIV-1 / immunology*
  • Mice
  • Models, Molecular
  • Molecular Conformation
  • Nanoparticles / chemistry*
  • Safety
  • Vaccines, DNA / adverse effects
  • Vaccines, DNA / chemistry*
  • Vaccines, DNA / immunology
  • Vaccines, Virus-Like Particle / adverse effects
  • Vaccines, Virus-Like Particle / chemistry*
  • Vaccines, Virus-Like Particle / immunology

Substances

  • AIDS Vaccines
  • Adjuvants, Immunologic
  • Fullerenes
  • Vaccines, DNA
  • Vaccines, Virus-Like Particle
  • fullerenol