Abstract
Brain metastases are a much-feared complication of cancer. The development of brain metastases requires a malignant cell to acquire characteristics that facilitate dissemination away from the primary site, entrance into the nervous system, and establishment in the brain. This review summarizes recent work focused on the molecular derangements leading to brain metastases and outlines areas in need of greater understanding.
MeSH terms
-
Animals
-
Antineoplastic Agents / pharmacology
-
Antineoplastic Agents / therapeutic use
-
Blood-Brain Barrier / pathology
-
Brain Neoplasms / genetics
-
Brain Neoplasms / metabolism
-
Brain Neoplasms / prevention & control
-
Brain Neoplasms / secondary*
-
Humans
-
Neoplasm Invasiveness
-
Organ Specificity
-
Receptor, ErbB-2 / genetics
-
Receptor, ErbB-2 / metabolism
Substances
-
Antineoplastic Agents
-
ERBB2 protein, human
-
Receptor, ErbB-2