Trisomy 13 and myelodysplastic syndrome

G C Beverstock; J E Ploem; H Wessels; D van de Keur; P Mollevanger

doi:10.1016/0165-4608(90)90117-s

Trisomy 13 and myelodysplastic syndrome

Cancer Genet Cytogenet. 1990 Sep;48(2):179-82. doi: 10.1016/0165-4608(90)90117-s.

Authors

G C Beverstock¹, J E Ploem, H Wessels, D van de Keur, P Mollevanger

Affiliation

¹ Department of Human Genetics, State University Hospital, Leiden, The Netherlands.

PMID: 2397449
DOI: 10.1016/0165-4608(90)90117-s

Abstract

The clinical and cytogenetic data of a patient with myelodysplastic syndrome-refractory anemia with excess blasts (MDS-RAEB) and trisomy 13 as the sole abnormality are presented. This appears to be only the second report of such a patient. The presence of trisomy 13 is confirmed by in situ hybridization using an alphoid repeat probe L1.26, which is specific for the centromeres of both chromosomes 13 and 21.

Publication types

Case Reports

MeSH terms

Aged
Anemia, Refractory, with Excess of Blasts / genetics
Chromosomes, Human, Pair 13*
Humans
Male
Myelodysplastic Syndromes / genetics*
Nucleic Acid Hybridization
Trisomy*