Translocation between chromosomes 8q24 and 14q11 in T-cell acute lymphoblastic leukemia

Cancer Genet Cytogenet. 1990 Oct 1;49(1):69-74. doi: 10.1016/0165-4608(90)90165-7.

Abstract

Cytogenetic study was performed on a patient with T-cell acute lymphoblastic leukemia (T-ALL). It revealed a chromosomal translocation between chromosome bands 8q24 and 14q11. 8q24 is known to encode the oncogene c-myc, while 14q11 encodes the genes for T-cell receptor-alpha (TCR-alpha) and T-cell receptor-delta (TCR-delta). Therefore, this chromosomal translocation t(8;14) (q24;q11) seemed to be unique and specific to T-cell malignancy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chromosome Banding
  • Chromosomes, Human, Pair 14*
  • Chromosomes, Human, Pair 8*
  • DNA Probes
  • Genetic Markers
  • Humans
  • Karyotyping
  • Leukemia-Lymphoma, Adult T-Cell / genetics*
  • Male
  • Nucleic Acid Hybridization
  • Proto-Oncogenes
  • Receptors, Antigen, T-Cell / genetics
  • Translocation, Genetic*

Substances

  • DNA Probes
  • Genetic Markers
  • Receptors, Antigen, T-Cell