The use of bayesian latent class cluster models to classify patterns of cognitive performance in healthy ageing

PLoS One. 2013 Aug 20;8(8):e71940. doi: 10.1371/journal.pone.0071940. eCollection 2013.

Abstract

The main focus of this study is to illustrate the applicability of latent class analysis in the assessment of cognitive performance profiles during ageing. Principal component analysis (PCA) was used to detect main cognitive dimensions (based on the neurocognitive test variables) and Bayesian latent class analysis (LCA) models (without constraints) were used to explore patterns of cognitive performance among community-dwelling older individuals. Gender, age and number of school years were explored as variables. Three cognitive dimensions were identified: general cognition (MMSE), memory (MEM) and executive (EXEC) function. Based on these, three latent classes of cognitive performance profiles (LC1 to LC3) were identified among the older adults. These classes corresponded to stronger to weaker performance patterns (LC1>LC2>LC3) across all dimensions; each latent class denoted the same hierarchy in the proportion of males, age and number of school years. Bayesian LCA provided a powerful tool to explore cognitive typologies among healthy cognitive agers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / psychology*
  • Bayes Theorem
  • Cluster Analysis
  • Cognition
  • Executive Function
  • Female
  • Health
  • Humans
  • Male
  • Markov Chains
  • Memory
  • Middle Aged
  • Models, Psychological*
  • Monte Carlo Method
  • Neuropsychological Tests

Grants and funding

The study is integrated in the “Maintaining health in old age through homeostasis (SWITCHBOX)” collaborative project funded by the European Commission FP7 initiative (grant HEALTH-F2-2010-259772). NS and JAP are main team members of the European consortium SWITCHBOX (http://www.switchbox-online.eu/). NCS is supported by a SwitchBox post-doctoral fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.