Slide to the left and slide to the right: motor coordination in neurons

Martin Harterink; Casper C Hoogenraad

doi:10.1016/j.devcel.2013.08.009

Slide to the left and slide to the right: motor coordination in neurons

Dev Cell. 2013 Aug 26;26(4):326-8. doi: 10.1016/j.devcel.2013.08.009.

Authors

Martin Harterink¹, Casper C Hoogenraad

Affiliation

¹ Cell Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

PMID: 23987508
DOI: 10.1016/j.devcel.2013.08.009

Abstract

Molecular motors employ specific adaptor proteins to dock on transport cargos. Reporting in The Journal of Cell Biology, Fu and Holzbaur (2013) show that the adaptor JNK interacting protein 1 (JIP1) binds kinesin-1 and dynactin and controls bidirectional axonal amyloid precursor protein trafficking, suggesting a regulatory role for adaptors during cargo transport.

Publication types

Comment

MeSH terms

Adaptor Proteins, Signal Transducing / metabolism*
Amyloid beta-Protein Precursor / metabolism*
Animals
Axonal Transport*
Dyneins / metabolism*
Kinesins / metabolism*

Substances

Adaptor Proteins, Signal Transducing
Amyloid beta-Protein Precursor
Dyneins
Kinesins