Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives

Theerachart Leepasert; Manochehr Shahabi; Karem Shanab; Eva Schirmer; Wolfgang Holzer; Helmut Spreitzer; Babette Aicher; Gilbert Müller; Eckhard Günther

doi:10.1016/j.bmcl.2013.08.021

Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives

Bioorg Med Chem Lett. 2013 Oct 1;23(19):5264-6. doi: 10.1016/j.bmcl.2013.08.021. Epub 2013 Aug 13.

Authors

Theerachart Leepasert¹, Manochehr Shahabi, Karem Shanab, Eva Schirmer, Wolfgang Holzer, Helmut Spreitzer, Babette Aicher, Gilbert Müller, Eckhard Günther

Affiliation

¹ Department of Drug and Natural Product Synthesis, University of Vienna, Vienna, Austria.

PMID: 23988351
DOI: 10.1016/j.bmcl.2013.08.021

Abstract

A new series of substituted tri-/tetraazabenzo[3,2-a]fluorene-5,6-diones and their corresponding oxime derivatives have been synthesized and spectroscopically characterized. The antiproliferative activities of all compounds were evaluated on at least three different cell lines.

Keywords: Anticancer compounds.

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Aza Compounds / chemical synthesis*
Aza Compounds / chemistry
Benzene Derivatives / chemical synthesis
Benzene Derivatives / chemistry
Cell Line, Tumor
Cell Proliferation / drug effects
Fluorenes / chemical synthesis*
Humans
Inhibitory Concentration 50
Molecular Structure

Substances

Antineoplastic Agents
Aza Compounds
Benzene Derivatives
Fluorenes