Blood lactate in HIV-infected children on antiretroviral therapy in rural South Africa

Mette S van Ramshorst; Helen E Struthers; James A McIntyre; Remco P H Peters

doi:10.1097/INF.0000000000000036

Blood lactate in HIV-infected children on antiretroviral therapy in rural South Africa

Pediatr Infect Dis J. 2014 Apr;33(4):393-5. doi: 10.1097/INF.0000000000000036.

Authors

Mette S van Ramshorst¹, Helen E Struthers, James A McIntyre, Remco P H Peters

Affiliation

¹ From the *Anova Health Institute, Johannesburg and Tzaneen, South Africa; †Department of Internal Medicine, University of Cape Town; and ‡School of Public Health, University of Cape Town, Cape Town, South Africa.

PMID: 23995586
DOI: 10.1097/INF.0000000000000036

Abstract

We studied blood lactate levels in 253 South African children on antiretroviral therapy. The prevalence of hyperlactatemia was 68% and severity was mild in most cases (69%). There was no association of symptoms and/or signs with hyperlactatemia. Independent predictors were lipo-dystrophy, time on antiretroviral therapy and baseline CD4 count. Increased awareness of hyperlactatemia in African children on antiretroviral therapy is warranted.

Publication types

Research Support, American Recovery and Reinvestment Act
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Anti-Retroviral Agents / adverse effects
Anti-Retroviral Agents / therapeutic use*
Child
Female
HIV Infections / blood*
HIV Infections / drug therapy*
HIV Infections / epidemiology
Humans
Hyperlactatemia / blood*
Hyperlactatemia / epidemiology
Hyperlactatemia / virology*
Lactic Acid / blood*
Male
Prevalence
Risk Factors
Rural Population
South Africa / epidemiology

Substances

Anti-Retroviral Agents
Lactic Acid