Abstract
Specialized cells in the body express high levels of V-ATPase in their plasma membrane and respond to hormonal and nonhormonal cues to regulate extracellular acidification. Mutations in or loss of some V-ATPase subunits cause several disorders, including renal distal tubular acidosis and male infertility. This review focuses on the regulation of V-ATPase-dependent luminal acidification in renal intercalated cells and epididymal clear cells, which are key players in these physiological processes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Acidosis, Renal Tubular / enzymology
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Acidosis, Renal Tubular / genetics
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Animals
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Cell Membrane / enzymology*
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Epididymis / enzymology*
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Genetic Predisposition to Disease
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Homeostasis
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Humans
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Hydrogen-Ion Concentration
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Infertility, Male / enzymology
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Infertility, Male / genetics
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Kidney / enzymology*
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Male
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Mutation
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Phenotype
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Vacuolar Proton-Translocating ATPases / chemistry
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Vacuolar Proton-Translocating ATPases / genetics
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Vacuolar Proton-Translocating ATPases / metabolism*
Substances
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Vacuolar Proton-Translocating ATPases