Polyphosphoester-based cationic nanoparticles serendipitously release integral biologically-active components to serve as novel degradable inducible nitric oxide synthase inhibitors

Adv Mater. 2013 Oct 18;25(39):5609-14. doi: 10.1002/adma.201302842. Epub 2013 Sep 3.

Abstract

A degradable polyphosphoester (PPE)-based cationic nanoparticle (cSCK), which is integrated constructed as a novel degradable drug device, demonstrates surprisingly efficient inhibition of inducible nitric oxide synthase (iNOS) transcription, and eventually inhibits nitric oxide (NO) over-production, without loading of any specific therapeutic drugs. This system may serve as a promising anti-inflammatory agent toward the treatment of acute lung injury.

Keywords: degradation; iNOS inhibition; integrated construction; polyphosphoester-based nanoparticle.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biological Transport
  • Cell Line
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / metabolism
  • Enzyme Inhibitors / pharmacology*
  • Esters
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Mice
  • Nanoparticles / chemistry*
  • Nitric Oxide / biosynthesis
  • Nitric Oxide Synthase Type II / antagonists & inhibitors*
  • Polymers / chemistry*
  • Polymers / metabolism
  • Polymers / pharmacology*

Substances

  • Enzyme Inhibitors
  • Esters
  • Polymers
  • Nitric Oxide
  • Nitric Oxide Synthase Type II