Chemoselective oxidative C(CO)-C(methyl) bond cleavage of methyl ketones to aldehydes catalyzed by CuI with molecular oxygen

Lin Zhang; Xihe Bi; Xiaoxue Guan; Xingqi Li; Qun Liu; Badru-Deen Barry; Peiqiu Liao

doi:10.1002/anie.201305010

Chemoselective oxidative C(CO)-C(methyl) bond cleavage of methyl ketones to aldehydes catalyzed by CuI with molecular oxygen

Angew Chem Int Ed Engl. 2013 Oct 18;52(43):11303-7. doi: 10.1002/anie.201305010. Epub 2013 Sep 2.

Authors

Lin Zhang¹, Xihe Bi, Xiaoxue Guan, Xingqi Li, Qun Liu, Badru-Deen Barry, Peiqiu Liao

Affiliation

¹ Department of Chemistry, Northeast Normal University, Changchun 130024 (China).

PMID: 24000196
DOI: 10.1002/anie.201305010

Abstract

Aldehyde Termination: A novel copper-catalyzed transformation from methyl ketones into aldehydes has been accomplished. This method is applicable to a wide range of aromatic and aliphatic methyl ketones and chemoselectively produces aldehydes, accompanied by the release of hydrogen (H2 ) and carbon dioxide (CO2 ) as by-products.

Keywords: aldehydes; cleavage reactions; copper; ketones; oxygen.