Abstract
Pyrrole polyamide-2'-deoxyguanosine 5'-phosphate hybrid (Hybrid 4) was synthesized and evaluated in terms of the inhibition of mouse mammary carcinoma FM3A cell growth. Hybrid 4 was found to exhibit dose-dependent inhibition of cell growth.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Deoxyguanine Nucleotides / chemical synthesis*
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Deoxyguanine Nucleotides / chemistry
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Deoxyguanine Nucleotides / pharmacology*
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Dose-Response Relationship, Drug
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Female
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Mammary Neoplasms, Animal
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Mice
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Molecular Structure
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Neoplasms / drug therapy
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Nylons / chemical synthesis
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Nylons / chemistry
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Nylons / pharmacology
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Pyrroles / chemical synthesis
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Pyrroles / chemistry
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Pyrroles / pharmacology
Substances
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Deoxyguanine Nucleotides
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Nylons
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Pyrroles
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2'-deoxyguanosine 5'-phosphate