Abstract
Various ester and thioester derivatives of hippuric acid have been prepared which were substrates of both beta-lactamases and DD-peptidases. The thioesters were more rapidly hydrolysed by nearly all the enzymes. Surprisingly, the enzymes acted rather efficiently on substrates which did not contain any chiral centre.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Chromogenic Compounds / metabolism*
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Esters
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Hydrolysis
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Kinetics
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Molecular Sequence Data
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Molecular Structure
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Muramoylpentapeptide Carboxypeptidase / metabolism*
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Oligopeptides / metabolism*
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Penicillins / pharmacology*
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Pronase / metabolism
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Substrate Specificity
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beta-Lactamases / metabolism*
Substances
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Chromogenic Compounds
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Esters
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Oligopeptides
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Penicillins
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Muramoylpentapeptide Carboxypeptidase
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Pronase
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beta-Lactamases