Abstract
In nude mice grieofulvin given by intraperitoneal injections produces a severe porphyric state within 1 week. Compared with peroral administration of griseofulvin to produce experimental porphyria, this model is much more efficient and can be more easily controlled.
MeSH terms
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Animals
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Chemical and Drug Induced Liver Injury*
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Chromatography, Liquid
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Disease Models, Animal
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Erythropoiesis / drug effects
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Griseofulvin* / administration & dosage
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Injections, Intraperitoneal
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Male
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Mice
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Mice, Nude
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Porphyrias / chemically induced*
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Porphyrins / blood*
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Protoporphyrins / blood*
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Skin Diseases / chemically induced*
Substances
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Porphyrins
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Protoporphyrins
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Griseofulvin