Bordetella bronchiseptica in a pediatric Cystic Fibrosis center

J Cyst Fibros. 2014 Jan;13(1):43-8. doi: 10.1016/j.jcf.2013.08.002. Epub 2013 Sep 4.

Abstract

Background: Bordetella bronchiseptica is a common pathogenic or colonizing organism of domestic mammals. In dogs, it causes an infectious tracheobronchitis known as Kennel Cough. Human infections are unusual and almost exclusively described in immunocompromised patients who have had contact with a known animal reservoir. It is rarely reported in Cystic Fibrosis (CF), possibly hampered by low recovery from culture and organism misidentification. We describe the incidence and characteristics of B. bronchiseptica in our CF population.

Methods: A retrospective cohort study was conducted of our center's CF patient population. Patients were included if they had B. bronchiseptica isolated on one or more occasion.

Results: Seven children with CF isolated B. bronchiseptica on 23 occasions, frequently associated with the symptoms of a pulmonary exacerbation. Four patients required hospitalization.

Conclusion: These results suggest that B. bronchiseptica may be more common than previously reported and may play a potential pathogenic role in CF.

Keywords: Animal; Bordetella bronchiseptica; Cystic Fibrosis; Pathogen.

MeSH terms

  • Adolescent
  • Animals
  • Anti-Bacterial Agents / therapeutic use
  • Bordetella Infections / diagnosis*
  • Bordetella Infections / drug therapy
  • Bordetella Infections / epidemiology
  • Bordetella bronchiseptica / immunology
  • Bordetella bronchiseptica / isolation & purification*
  • Child
  • Child, Preschool
  • Cystic Fibrosis / epidemiology
  • Cystic Fibrosis / immunology
  • Cystic Fibrosis / microbiology*
  • Dog Diseases / epidemiology
  • Dog Diseases / microbiology
  • Dogs
  • Female
  • Humans
  • Immunocompromised Host*
  • Incidence
  • Infant
  • Male
  • Respiratory Tract Infections / drug therapy
  • Respiratory Tract Infections / epidemiology
  • Respiratory Tract Infections / microbiology*
  • Retrospective Studies
  • Treatment Outcome
  • Young Adult

Substances

  • Anti-Bacterial Agents