Continuous-flow solid-phase synthesis of potential antigenic peptides of hepatitis B virus

F Rabanal; I Haro; F Reig; J M García-Antón

doi:10.1111/j.1399-3011.1990.tb00080.x

Continuous-flow solid-phase synthesis of potential antigenic peptides of hepatitis B virus

Int J Pept Protein Res. 1990 Jul;36(1):26-30. doi: 10.1111/j.1399-3011.1990.tb00080.x.

Authors

F Rabanal¹, I Haro, F Reig, J M García-Antón

Affiliation

¹ Laboratory of Peptides, C.I.D., C.S.I.C., Barcelona, Spain.

PMID: 2401598
DOI: 10.1111/j.1399-3011.1990.tb00080.x

Abstract

The synthesis of three hepatitis B surface antigens derived from S and pre-S proteins (adw S(140-147), [Tyr148] adw S(139-148), and adw pre-S(120-145)) has been accomplished by the continuous flow Fmoc-polyamide solid phase method. The use of different scavengers and trimethylsilyl bromide (TMSBr) in trifluoroacetic acid as deprotecting procedures is discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Hepatitis B Antigens / chemical synthesis*
Hepatitis B Antigens / isolation & purification
Hepatitis B Surface Antigens / chemical synthesis
Molecular Sequence Data
Peptides / chemical synthesis*
Peptides / immunology
Peptides / isolation & purification

Substances

Hepatitis B Antigens
Hepatitis B Surface Antigens
Peptides