Human PPP1R26P1 functions as cis-repressive element in mouse Rb1

PLoS One. 2013 Sep 3;8(9):e74159. doi: 10.1371/journal.pone.0074159. eCollection 2013.

Abstract

The human retinoblastoma gene (RB1) is imprinted; the mouse Rb1 gene is not. Imprinted expression of RB1 is due to differential methylation of a CpG island (CpG85), which is located in the pseudogene PPP1R26P1 in intron 2 of RB1. CpG85 serves as promoter for an alternative RB1 transcript, which is expressed from the unmethylated paternal allele only and is thought to suppress expression of the full-length RB1 transcript in cis. PPP1R26P1 contains another CpG island (CpG42), which is biallelically methylated. To determine the influence of PPP1R26P1 on RB1 expression, we generated an in vitro murine embryonic stem cell model by introducing human PPP1R26P1 into mouse Rb1. Next generation bisulfite sequencing of CpG85 and CpG42 revealed differences in their susceptibility to DNA methylation, gaining methylation at a median level of 4% and 18%, respectively. We showed binding of RNA polymerase II at and transcription from the unmethylated CpG85 in PPP1R26P1 and observed reduced expression of full-length Rb1 from the targeted allele. Our results identify human PPP1R26P1 as a cis-repressive element and support a connection between retrotransposition of PPP1R26P1 into human RB1 and the reduced expression of RB1 on the paternal allele.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CpG Islands
  • DNA Methylation
  • Embryonic Stem Cells / metabolism
  • Humans
  • Introns
  • Mice
  • Pseudogenes*
  • RNA, Messenger / genetics
  • Repressor Proteins / genetics*
  • Retinoblastoma Protein / genetics*
  • Transcription, Genetic

Substances

  • RNA, Messenger
  • Repressor Proteins
  • Retinoblastoma Protein

Grants and funding

This work was supported by the Deutsche Forschungsgemeinschaft (grant LO530/7-1 to DL, KB and LS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.