A comparative study between brain conventional computed tomography (CT) examinations and low-dose examinations was performed. The aim of the work was to show if a low-dose technique can be used instead of a standard one. Forty patients with 51 brain lesions were studied with both techniques. The low-dose technique was optimized with mAs reduction to obtain a 25% dose reduction compared to standard acquisitions. Even if images have a poor signal-to-noise ratio, the low-dose technique visualized all the lesions disclosed by conventional examination except three chronic vascular lacunar infarcts. In conclusion, the low-dose technique can be adopted instead conventional CT scans in selected cases.