Abstract
This study aimed to verify the impact of heart magnetic resonance imaging on chelation choices and patient compliance in a single-institution cohort as well as its predictive value for heart failure and arrhythmias. Abnormal cardiac T2* values determined changes in treatment in most subjects. Heart T2* was confirmed to be highly predictive over 1 year for heart failure and arrhythmias. The choice of chelation regimens known to remove heart iron efficiently was not sufficient by itself to influence the risk. Compliance with treatment had a more remarkable role.
Keywords:
arrhythmia; beta thalassaemia major; compliance; heart failure; heart magnetic resonance imaging.
© 2013 John Wiley & Sons Ltd.
MeSH terms
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Adult
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Area Under Curve
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Arrhythmias, Cardiac / epidemiology
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Arrhythmias, Cardiac / etiology*
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Arrhythmias, Cardiac / prevention & control
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Benzoates / administration & dosage
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Benzoates / therapeutic use
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Chelation Therapy / methods*
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Deferasirox
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Deferiprone
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Deferoxamine / administration & dosage
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Deferoxamine / therapeutic use
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Dose-Response Relationship, Drug
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Drug Therapy, Combination
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Female
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Heart Failure / epidemiology
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Heart Failure / etiology*
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Heart Failure / prevention & control
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Humans
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Iron / analysis
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Iron Chelating Agents / administration & dosage
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Iron Chelating Agents / therapeutic use*
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Iron Overload / diagnosis*
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Iron Overload / etiology
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Iron Overload / pathology
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Iron Overload / prevention & control
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Magnetic Resonance Imaging*
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Male
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Myocardium / chemistry
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Myocardium / pathology*
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Patient Compliance*
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Predictive Value of Tests
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Pyridones / administration & dosage
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Pyridones / therapeutic use
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ROC Curve
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Risk
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Sampling Studies
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Transfusion Reaction
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Triazoles / administration & dosage
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Triazoles / therapeutic use
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Young Adult
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beta-Thalassemia / complications
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beta-Thalassemia / drug therapy
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beta-Thalassemia / pathology*
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beta-Thalassemia / therapy
Substances
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Benzoates
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Iron Chelating Agents
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Pyridones
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Triazoles
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Deferiprone
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Iron
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Deferoxamine
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Deferasirox