Self-eating limits EGFR-dependent tumor growth

Valeria R Fantin; Robert T Abraham

doi:10.1016/j.cell.2013.08.040

Self-eating limits EGFR-dependent tumor growth

Cell. 2013 Sep 12;154(6):1184-6. doi: 10.1016/j.cell.2013.08.040.

Authors

Valeria R Fantin¹, Robert T Abraham

Affiliation

¹ Oncology Research Unit, Pfizer Worldwide Research and Development, La Jolla, CA 92121, USA.

PMID: 24034240
DOI: 10.1016/j.cell.2013.08.040

Abstract

Autophagy is a cell-autonomous, catabolic process that plays context-dependent roles in tumor growth and progression. Wei et al. report that EGFR signaling promotes tumor growth through phosphorylation and functional inactivation of Beclin 1 and the consequent suppression of autophagy.

Publication types

Comment

MeSH terms

Animals
Apoptosis Regulatory Proteins / metabolism*
Autophagy*
Beclin-1
Drug Resistance, Neoplasm*
ErbB Receptors / metabolism*
Humans
Membrane Proteins / metabolism*

Substances

Apoptosis Regulatory Proteins
BECN1 protein, human
Beclin-1
Membrane Proteins
EGFR protein, human
ErbB Receptors