Cholera toxin notches epithelial junctions

Cell Host Microbe. 2013 Sep 11;14(3):227-9. doi: 10.1016/j.chom.2013.08.009.

Abstract

Cholera toxin (CT) is the factor responsible for watery diarrhea associated with Vibrio cholerae infection. In this issue, Guichard et al. (2013) report that CT compromises intestinal epithelium barrier function via cyclic AMP (cAMP)-induced disruption of Rab11- and exocyst-dependent delivery of endocytic recycling cargo to cell-cell junctions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Cholera Toxin / metabolism*
  • Epithelial Cells / physiology*
  • Exosomes / drug effects*
  • Host-Pathogen Interactions*
  • Humans
  • Tight Junction Proteins / antagonists & inhibitors*
  • Tight Junctions / physiology*
  • Vibrio cholerae / physiology*

Substances

  • Tight Junction Proteins
  • Cholera Toxin