Serum cyclophilin A concentrations in renal transplant recipients receiving cyclosporine A: clinical implications for gingival overgrowth

Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Oct;116(4):447-54. doi: 10.1016/j.oooo.2013.06.021.

Abstract

Objective: The aim of this study was to investigate the clinical factors in relation to the cyclosporine A (CsA) induced gingival overgrowth (GO).

Study design: Seventy-three participants were assigned as GO+ and GO-. Factors including demographic, pharmacological, gingival variables and the serum cyclophilin A (CyPA) concentration were analyzed.

Results: The occurrence of GO was 39.72%. Papillary bleeding index (PBI) had a significantly higher risk of GO than plaque index (PI), the ratio of CsA to CyPA, and serum CyPA concentration (odds ratio = 364.323, 25.791, 1.002, 0.096, respectively). The severity of GO correlated with PI, the ratio of CsA to CyPA, PBI, serum concentrations of CsA and CyPA (r = 0.366, 0.355, 0.344, 0.305, and -0.232, respectively).

Conclusions: Since a cross-sectional study is not able to explain whether plaque and inflammation are the cause or consequence of GO, the ratio of CsA to CyPA may be a valuable marker for predicting GO.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analysis of Variance
  • Cross-Sectional Studies
  • Cyclophilin A / blood*
  • Cyclosporine / administration & dosage
  • Cyclosporine / adverse effects*
  • Dental Plaque Index
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Gingival Overgrowth / chemically induced*
  • Gingival Overgrowth / pathology
  • Humans
  • Immunosuppression Therapy / adverse effects*
  • Immunosuppressive Agents / adverse effects*
  • Kidney Transplantation*
  • Luminescent Measurements
  • Male
  • Middle Aged
  • Severity of Illness Index

Substances

  • Immunosuppressive Agents
  • Cyclosporine
  • Cyclophilin A