Successful cure of C1q deficiency in human subjects treated with hematopoietic stem cell transplantation

J Allergy Clin Immunol. 2014 Jan;133(1):265-7. doi: 10.1016/j.jaci.2013.07.035. Epub 2013 Sep 12.

Authors

Peter D Arkwright¹, Philip Riley², Stephen M Hughes², Hana Alachkar³, Robert F Wynn²

Affiliations

¹ Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom; Departments of Paediatric Immunology, Rheumatology and Bone Marrow Transplantation, Royal Manchester Children's Hospital, Manchester, United Kingdom. Electronic address: [email protected].
² Departments of Paediatric Immunology, Rheumatology and Bone Marrow Transplantation, Royal Manchester Children's Hospital, Manchester, United Kingdom.
³ Department of Immunology, Salford Royal Foundation Trust, Manchester, United Kingdom.

PMID: 24035158
DOI: 10.1016/j.jaci.2013.07.035

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Adolescent
Alemtuzumab
Antibodies, Monoclonal, Humanized / administration & dosage
Antibodies, Monoclonal, Murine-Derived / administration & dosage
Autoantibodies / blood
Cardiolipins / immunology
Child
Child, Preschool
Chimerism
Complement C1q / genetics*
Consanguinity
Disease-Free Survival
Graft vs Host Disease / etiology
Graft vs Host Disease / prevention & control*
Hematopoietic Stem Cell Transplantation*
Humans
Immunologic Deficiency Syndromes / immunology
Immunologic Deficiency Syndromes / therapy*
Male
Pakistan
Pedigree
Postoperative Complications / prevention & control*
Recovery of Function
Ribonucleoproteins / immunology
Rituximab
Transplantation Conditioning / methods

Substances

Antibodies, Monoclonal, Humanized
Antibodies, Monoclonal, Murine-Derived
Autoantibodies
Cardiolipins
Ribonucleoproteins
SS-A antigen
Alemtuzumab
Rituximab
Complement C1q