Intrathyroidal parathyroid carcinoma mimicking a thyroid nodule in a MEN type 1 patient

J Clin Ultrasound. 2014 May;42(4):212-4. doi: 10.1002/jcu.22090. Epub 2013 Sep 4.

Abstract

A 59-year-old woman with classic manifestations of hyperparathyroidism associated with multiple endocrine neoplasia type 1 presented with a right adrenal mass and two pituitary microadenomas on imaging studies. For evaluation of hypercalcemia, (99m) Tc-MIBI scintigraphy was done and showed focal uptake at the thyroid level of the right anterior neck. Subsequent neck sonography showed several thyroid nodules, but there was no parathyroid tumor. Percutaneous fine-needle aspiration of the dominant thyroid nodule indicated a follicular nodule. After surgery, final histopathology revealed intrathyroidal parathyroid carcinoma. This case illustrates the difficulty in diagnosing parathyroid carcinoma via fine-needle aspiration.

Keywords: multiple endocrine neoplasia type 1; parathyroid, carcinoma, ectopic location; ultrasonography.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / diagnostic imaging*
  • Adenoma / surgery
  • Diagnosis, Differential
  • Female
  • Humans
  • Middle Aged
  • Multiple Endocrine Neoplasia Type 1 / complications*
  • Parathyroid Glands / diagnostic imaging*
  • Parathyroid Glands / surgery
  • Parathyroid Neoplasms / complications*
  • Parathyroid Neoplasms / diagnostic imaging*
  • Parathyroid Neoplasms / surgery
  • Thyroid Neoplasms / diagnosis
  • Thyroid Nodule / diagnosis
  • Ultrasonography