Stabilization of peptides for intracellular applications by phosphoramidate-linked polyethylene glycol chains

Angew Chem Int Ed Engl. 2013 Nov 4;52(45):11920-4. doi: 10.1002/anie.201303467. Epub 2013 Aug 22.

Authors

Nicole Nischan¹, Alokta Chakrabarti, Remigiusz A Serwa, Petra H M Bovee-Geurts, Roland Brock, Christian P R Hackenberger

Affiliation

¹ Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Strasse 10, 13125 Berlin (Germany); Humboldt Universität zu Berlin, Department Chemie, Brook-Taylor-Strasse 2, 12489 Berlin (Germany); Freie Universität Berlin, Institut für Chemie und Biochemie, Takustrasse 3, 14195 Berlin (Germany).

PMID: 24039043
DOI: 10.1002/anie.201303467

No abstract available

Keywords: PEGylation; Staudinger-phosphite reaction; apoptosis; peptides; proteolysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amides / chemistry*
Apoptosis
Humans
Jurkat Cells
Peptides
Phosphoric Acids / chemistry*
Polyethylene Glycols / chemistry*
Proteolysis

Substances

Amides
Peptides
Phosphoric Acids
Polyethylene Glycols
phosphoramidic acid