Abstract
Esophageal cancer (EC), mainly consisting of squamous cell carcinoma (ESCC) in the Eastern world and adenocarcinoma (EAC) in the Western world, is strongly associated with dietary factors such as alcohol use. We aimed to clarify the modifying role in EC etiology in Caucasians of functional genotypes in alcohol-metabolizing enzymes. In all, 351 Caucasian patients with EC and 430 matched controls were included and polymorphisms in CYP2E1, ADH and near ALDH2 genes were determined. In contrast to the results on ESCC in mainly Asian studies, we found that functional genotypes of alcohol-metabolizing enzymes were not significantly associated with EAC or ESCC in an European population.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / enzymology
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Adenocarcinoma / ethnology
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Adenocarcinoma / genetics*
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Aged
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Alcohol Dehydrogenase / genetics*
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Alcohol Dehydrogenase / metabolism
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Carcinoma, Squamous Cell / enzymology
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Carcinoma, Squamous Cell / ethnology
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Carcinoma, Squamous Cell / genetics*
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Case-Control Studies
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Cytochrome P-450 CYP2E1 / genetics*
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Cytochrome P-450 CYP2E1 / metabolism
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Esophageal Neoplasms / enzymology
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Esophageal Neoplasms / ethnology
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Esophageal Neoplasms / genetics*
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Esophageal Squamous Cell Carcinoma
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Ethanol / metabolism*
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Female
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Genetic Association Studies
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Genetic Predisposition to Disease
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Humans
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Male
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Middle Aged
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Netherlands
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Polymorphism, Genetic
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White People*
Substances
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Ethanol
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Alcohol Dehydrogenase
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Cytochrome P-450 CYP2E1
Supplementary concepts
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Adenocarcinoma Of Esophagus